Flora Hamilton met Elijah Taylor Cassel at Shurtleff College in Alton, Illinois, where they were both students. They married in 1874 and moved to Hastings in 1887. In their home on the south side of Hastings, Flora had a music store on the first floor and Dr. Cassel practiced homeopathic medicine on the second floor. Flora taught piano and organ while selling musical instruments. She often loaded organs and pianos into her buckboard and delivered them herself.
Flora was active in the Clay and Adams County Woman’s Christian Temperance Union. In 1890, she published White Ribbon Vibrations, a songbook focusing on the temperance movement. Of the 116 songs, Flora wrote lyrics and music for 40 of them. She received little financial gain from her songs, but they were performed by church people and temperance workers across the United States.